Category Archives: Big picture

Have We Wasted 7 Years and $100 Million Dollars on GWAS Studies?

Type 2 Diabetes, Rheumatoid Arthritis, Obesity, Chrohn’s Diseases and Coronary Heart Disease are examples of common, chronic diseases that have a significant genetic component. It should be no surprise that these diseases have been the target of much genetic research. Yet over the past decade, the tools of our research efforts have failed to unravel the complete biological architecture of… Read more »

Is Free Software Really Free?

The prevalence of open-source bioinformatic tools in the genetic research space is enormous. According to The North Shore LIJ Research Institute, there are over 500 genetic analysis software packages – the great majority of which are free – as of August 2010. Open-source tools are incredibly important in genetics. They allow new methodologies to be created and expanded. They tie… Read more »

Learning From Our GWAS Mistakes: From experimental design to scientific method

This month Biostatistics published online an open access article I co-authored with Dr. Laura Black from Montana State University: “Learning From Our GWAS Mistakes: From Experimental Design To Scientific Method.” The paper version is expected to come out in the April 2012 issue. I’m hoping that you will take the time to read it. And I’m hoping you will violently… Read more »

Never Let the Important Become Urgent: A reflection on the genetics supply chain and our need to increase value to the end patient

The turning of the calendar from 2011 to 2012 has been a good time for me to reflect on the lessons of the year and make resolutions for the new one. It is also the opportunity to step back and look at some of the larger systemic trends in our field and think about whether we are doing as much… Read more »

Leaky Sprinklers and “The Future of NGS Market Study 2011”

Have you ever chosen to do something yourself instead of paying money for the alternative, when, in the long run, the alternative is not really that expensive? We all have, as we all have limited budgets. One particular example comes to mind in my own life. My boyfriend, Ben, and I bought a house in April. Unfortunately, it wasn’t properly… Read more »