AboutWelcome to the Our 2 SNPs...® blog by Golden Helix, a leading bioinformatics company. This blog seeks to inform our customers and the genetic research community as a whole on the latest in analysis methods, best practices, and the future of the industry.
Please, don’t be shy! We want to hear your two SNPs as well! Also, if there is a specific topic that you would like to hear more about, please contact us at firstname.lastname@example.org. For more information about Golden Helix, visit our main site.
- About GHI (8)
- Add-on scripts & data repository (12)
- Assessment of new methods (5)
- Best practices in genetic analysis (16)
- Big picture (22)
- Bioinformatic support (9)
- Clinical genetics (6)
- Customer success (18)
- General statistical genetics principles (6)
- How to's and advanced workflows (14)
- News, events, & announcements (45)
- Paper review (2)
- Personal genomics (7)
- Plant & animal (6)
- Technology review (25)
- The Next Chapter of Golden Helix: Our Launch of SVS 8
- First Golden Helix Research Competition a Great Success!
- The New Human Genome Reference and Clinical Grade Annotations: It’s All About the Coordinates
- Public Data? What’s that good for anyway?
- Fun in the Sun – Headed to Tri-Con and AGBT next week
Category Archives: Technology review
Tis the season of quiet, productive hours. I’ve been spending a lot of mine thinking about file formats. Actually I’ve been spending mine implementing a new one, but more on that later. File formats are amazingly important in big data … Continue reading
Comparing BEAGLE, IMPUTE2, and Minimac Imputation Methods for Accuracy, Computation Time, and Memory Usage
Genotype imputation is a common and useful practice that allows GWAS researchers to analyze untyped SNPs without the cost of genotyping millions of additional SNPs. In the Services Department at Golden Helix, we often perform imputation on client data, and … Continue reading
Thanks to everyone for the great webcast yesterday. We had over 850 people register for the event and actually broke the record! Take that Bryce and Gabe! If you would like to see the recording, view it at: Mixed Models: … Continue reading
When researchers realized they needed a way to report genetic variants in scientific literature using a consistent format, the Human Genome Variation Society (HGVS) mutation nomenclature was developed and quickly became the standard method for describing sequence variations. Increasingly, HGVS … Continue reading
I’m a believer in the signal. Whole genomes and exomes have lots of signal. Man, is it cool to look at a pile-up and see a mutation as clear as day that you arrived at after filtering through hundreds of … Continue reading
Editor’s Note by Gabe Rudy: I’ve had the chance to exchange thoughts, emails, and blog post comments for a while now with Jeff as he has written posts on NGS Leaders and engaged with me on 23andMe. He has also … Continue reading
It has now been about a year since Illumina and Affymetrix announced their respective exome genotyping arrays. Both products were launched with ambitious visions of how they would enable researchers to learn significantly more about the cause of human diseases. … Continue reading
Today I ran into an interesting fact about how a prolifically used catalog of population controls classifies African Americans with potential impacts on research outcomes. The 1000 Genomes Project is arguably our best common set of controls used in genomic … Continue reading
Type 2 Diabetes, Rheumatoid Arthritis, Obesity, Chrohn’s Diseases and Coronary Heart Disease are examples of common, chronic diseases that have a significant genetic component. It should be no surprise that these diseases have been the target of much genetic research. … Continue reading